Compounds of the norpinane series and method of making



Patented Sept. 16, 1947 UNITED STATES PATENT OFFICE,

COMPOUNDS OF THE NORPINANE SERIES AND LIETHOD OF MAKING Joseph Paul Bain, Jacksonville, Fla., assignor, by mesne assignments, to The Glidden Company, Cleveland, Ohio, a corporation of Ohio No Drawing. Application January 6, 1944, Serial No. 517,218

. Claims. (Cl. 260-489) mo cmon The alcohol has the following approximate characteristics:

Since the product i prepared from nopinene and is an alcohol, it will be referred to as It, and certain of its derivatives may be considered as apopinene compounds, but since there is no established numbering system for apopinane applicant will herein consider the compounds as being substituted norpinane compounds, the numbering system for norpinane being:

Beta pinene, according to this system is 6,6 dimethyl-2 methylene-norpinane, and nopol is B(6,6 vdimethyl norpin-2-ene-2-) ethanol.

It has'been found that the double bond of nopol may be hydrogenated to produce a new series of compounds of the pinane group. Such compounds do not exhibit the tendency to thermal isomerization shown by nopol and its esters. Also the new compounds do not in general exhibit the "pinene reactions which are exhibited by nopol and its esters. The new compounds are therefore more stable. Primary terpene alcohols as well as terpene acid and aldehydes are useful in the medicinal, insecticidal and other fields and the stable products of the present invention are useful in such fields.

Example I were heated at to C. The parafo'rmaldehyde gradually dissolves in the-course of several hours to give a clear solution. The crude nopol was distilled at l08-l12 C. at 10 mm. pressure. In another experiment 408 parts of 'nopinene and 60 parts of paraformaldehyde were heated in an autoclave at 200 C. for 3 hours. The crude alcohol was distilled under 10 mm. at 110-112 C.

Example II 322 grams of nopol was hydrogenated at 1000 to 1500 lbs/sq. in. pressure in the presence of 5 grams of Raney nickel catalyst at a temperature of 180-200 C. In 4.5 hours the alcohol had ab- The density of 25 C. was 0.961.

Example!!! 84 grams of hydronopol were refluxed with 150 grams of acetic anhydride. The formed acetic acid was fractionated off and the ester fractionated at mm. An 83% yield was obtained of pure hydronopyl acetate having a boiling point at 10 mm. of 125-127 0., N 1.4700- 1.4708, and an optical rotation a '=21.96. The density at C. was 0.976.

Example IV 56 grams of hydronopol were dissolved in glacial acetic acid. A cool solution of 55 grams of chromium trioxide in 400 cc. acetic acid and 50 cc. of water was gradually added, the solutionbeing cooled to keep the temperature below 60 C. After the addition of the oxidizing agent was complete, the mixture was warmed to 75 C. and poured into water. This mixture was then extracted with several portions of ether and the ether extracted with 10% NaOH. The soap solution was then extracted with ether to remove neutral materials and acidified. The precipitated oily acid was extracted with ether and the ether ace'taldehyde, distilled at 95-100 0.1% 1.4805.

alpha (10 cm. tube) -13.5. For purification it was shaken with a saturated solution of sodium bisulfite, the solid addition product formed was washed with hexane and dried. 0n dissolving the addition product in water and adding sodium carbonate the pure aldehyde was liberated. It

yielded a semi-carbazone of melting point 161- 161.5 C., (alpha) -19.0 (2.0% in isopropanol).

Example VI Three hundred and twenty-five parts by weight of hydronopol dissolved in 500 parts pyridine was treated slowly at about 50 to 60 C. with 260 parts thiony1 chloride. After the addition of the thionyl chloride was complete the mixture was 20 mm. pressure.

solution evaporated. On cooling the residue crystallized to give a high yield of the crude hydronopic acid, 6,6, dimethyl norpinane-Z-acetic acid. Recrystallization from aqueous methanol gave the pure acid having a melting point of 56-58 C.

Neutral equivalent calculated for hydronopic acid, 182.25; found 182.8, 181.8.

Example V- Hydronopol was oxidized to the aldehyde by chromium trioxide in water solution at about ,75 C. The alcohol, 168 parts, was stirred with 350 parts water containing 40 parts sulfuric acid.

Calculated to standard conditions of temperature and pressure.

desired Product was separated and fractionated' The desired product, B(6,6-dimethyl norpinane- 2) ethyl chloride distilled at 122 to 123 C. at The density of the product was 0.9993 at 25 C., the optical rotation -29 (10 cm. tube) and the refractive index 1.4879 at 25 C. On analysis it was found to contain 19.03% chlorine.

Example VII Thirty grams of sodium was dissolved in 500 cc. butanol and grams hydronopyl chloride was added slowly and with agitation to the sodium butylate solution which was held near the boiling point. After addition of the chloride was complete the solution was refluxed for six hours to complete the reaction. The solution was then washed with water to remove suspended sodium chloride and excess alkali. The excess butanol was removed by fractionation and then the butyl ether of hydronopol was distilled, it boiled at 136 to 137 C. at 10 mm the product weighed 87 grams. This product had a density of 0.8925 at 25, an optical rotation of -20.4 (10 cm. tube) and refractive index 1.4663 at 19.3 C.

Example VIII ing the sodium alcoholate of hydronopol and then reacting with an alkyl halide such as'methyl or ethyl iodide to form the methyl and ethyl hydronopyl ethers.

It is thus seen that the present invention contemplates a new series of compounds, including 6,6, dimethyl compounds of the norpinane series also having a substituent group on the 2 carbon atom which contain a carbon-oxygen linkage involving the carbon atom B with respect to the number 2 carbon atom of the norpinane carbon structure. However, the nopol may be completely hydrogenated to the hydrocarbon.

The compounds contemplated by the present invention may, therefore, be broadly described as 6,6, dimethyl compounds of the norpinane series having a substituent group attached to the number two carbon atom of the nucleus said substituent group containing an uninterrupted carbon chain of at least two carbon atoms adjacent to the nuclear carbon atom.

The foregoing reactions are illustrated in the following scheme in" which the alpha pinene in which RLis ,a radical-selected from the group structure or nopol is\employed: V consisting of H, carboxylic acyl and lower alkyl.

cmcoox 7 011100011 cmcno n on, 1: cm 11 cm Reduction Alcohols HOV-EC? CHI 5;; CHI lac-HIGH CHI Oxidation l H l I t E H1 H: H:

v1 0 iv l OxidatiVxldntion I CHaCHsOH CHaCHaOH CHQCH! t on no on, n 0

Hl H: I no --cn| Y cm no--cn, on, 3 Hc--cm om H H H or! I on: 11 em 0 III Adds 1 0 1! g CHICHlCl CHaCHz-O R CEICHIONB \1 H OH: H CH:

HC-CH2 CH: \CHI H SH:

VIII IRONn CHlCHsOR 3. 11 cm HO --CH1 CH1 IX 1. Nopol 340,0 dimethyl uorpln-2-ene-2) ethanol.

II. Hydronopol B(6,6-dimethyl-norpinane-2) ethanol.

III. 6,6 dimethyi-2-ethyi uorpinane. I

IV. 6,6 dlmeth lnorpinane-2-aeetic acid. I

V. 6,6 dimethy norpinane-2-acetaldehyde.

VI. Esters and salts of IV.

VII. Alcoholate 0! II.

VIII. Hydrono ylchlorldeB(6,6 dimethyl norpinane-2-) ethyl chloride.

IX. Ethers olI X. Esters 0! II.

Having described the invention what is claimed 4. A chemical compound as claimed in claim 3 wherein R is the acetyl radical.

1. The process which comprises hydrogenating 6o 5. A chemical compound as claimed in claim 3 the double bond or the dicycllc primary alcohol wherein R is the butyl radical.

formed by condensing anhydrous formaldehyde JOSEPH PAUL BAIhl'. with nopinene at a temperature of 100 to 225 C. whereby B(6,6 dlmethyl norpinane-2-) eth- REFERENCES CITED anol is formed. v

2. B(6,6 dimethy1n0rpinane-2-) ethanol. 3. A chemical compound having the formula:

file of this patent:

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